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    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">IPROC</journal-id>
            <journal-id journal-id-type="nlm-ta">iProc</journal-id>
            <journal-title>Iproceedings</journal-title>
            <issn pub-type="epub">23696893</issn>
            <publisher>
                <publisher-name>JMIR Publications Inc.</publisher-name>
                <publisher-loc>Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v1i1e19</article-id>
            <article-id pub-id-type="pmid" />
            <article-id pub-id-type="doi">10.2196/iproc.4772</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Abstract</subject>
                </subj-group>
                <subj-group subj-group-type="article-type">
                    <subject>Abstract</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>Predictive Modeling of Emergency Hospital Transport Using Medical Alert Pattern Data: Retrospective Cohort Study</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Chen</surname>
                        <given-names>Karen</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Gouripeddi</surname>
                        <given-names>Ram</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1" corresp="yes">
                    <name name-style="western">
                        <surname>op den Buijs</surname>
                        <given-names>Jorn</given-names>
                    </name>
                    <degrees>Ph. D</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <address>
                        <institution>Philips Research</institution>
                        <addr-line>HTC 34.5.038</addr-line>
                        <addr-line>High Tech Campus 34</addr-line>
                        <addr-line>Eindhoven, 5656AE</addr-line>
                        <country>Netherlands</country>
                        <phone>31 631926890</phone>
                        <fax>31 000000000</fax>
                        <email>jorn.op.den.buijs@philips.com</email>
                    </address>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-8101-285X</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib2">
                    <name name-style="western">
                        <surname>Smits</surname>
                        <given-names>Tine</given-names>
                    </name>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-0674-2315</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib3">
                    <name name-style="western">
                        <surname>Pijl</surname>
                        <given-names>Marten</given-names>
                    </name>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-2604-9622</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib4">
                    <name name-style="western">
                        <surname>Simons</surname>
                        <given-names>Mariana</given-names>
                    </name>
                    <degrees>Ph. D</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-5772-059X</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib5">
                    <name name-style="western">
                        <surname>Schertzer</surname>
                        <given-names>Linda</given-names>
                    </name>
                    <xref rid="aff2" ref-type="aff">2</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-9955-8466</ext-link>
                </contrib>
            </contrib-group>
            <aff id="aff1">
                <sup>1</sup>
                <institution>Philips Research</institution>
                <addr-line>Eindhoven</addr-line>
                <country>Netherlands</country>
            </aff>
            <aff id="aff2">
                <sup>2</sup>
                <institution>Philips Home Monitoring</institution>
                <addr-line>Framingham, MA</addr-line>
                <country>United States</country>
            </aff>
            <author-notes>
                <corresp>Corresponding Author: Jorn op den Buijs <email>jorn.op.den.buijs@philips.com</email>
                </corresp>
            </author-notes>
            <pub-date pub-type="collection">
                <season>Oct-Dec</season>
                <year>2015</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>27</day>
                <month>10</month>
                <year>2015</year>
            </pub-date>
            <volume>1</volume>
            <issue>1</issue>
            <elocation-id>e19</elocation-id>
            <!--history from ojs - api-xml-->
            <history>
                <date date-type="received">
                    <day>29</day>
                    <month>5</month>
                    <year>2015</year>
                </date>
                <date date-type="rev-request">
                    <day>25</day>
                    <month>6</month>
                    <year>2015</year>
                </date>
                <date date-type="accepted">
                    <day>20</day>
                    <month>7</month>
                    <year>2015</year>
                </date>
            </history>
            <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
            <copyright-statement>&#169;Jorn op den Buijs, Tine Smits, Marten Pijl, Mariana Simons, Linda Schertzer. Originally published in JMIR Mhealth and Uhealth (http://www.iproc.org), 27.10.2015. </copyright-statement>
            <copyright-year>2015</copyright-year>
            <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
                <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mhealth and uhealth, is properly cited. The complete bibliographic information, a link to the original publication on http://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
            </license>
            <self-uri xlink:href="http://www.iproc.org/2015/1/e19/" xlink:type="simple" />
            <abstract>
                <sec sec-type="background">
                    <title>Background</title>
                    <p>In the transition from a fee-for-service to a fee-for-value system, health care organizations (HCOs) are under pressure to keep patients healthy through preventive services and population health management. Predictive analytics based on the past health behavior of the patient population can be used to predict future risk of decline.</p>
                </sec>
                <sec sec-type="objective">
                    <title>Objective</title>
                    <p>The objective of this study was to develop robust predictive models of impending emergency transports to the hospital based on enrollment and medical alert pattern data from subscribers of a Personal Emergency Response System (PERS) service. This enables targeting of clinical programs to members that need it the most.</p>
                </sec>
                <sec sec-type="methods">
                    <title>Methods</title>
                    <p>De-identified medical alert pattern data of 551,127 subscribers to a PERS service were used. Multivariate logistic regression was performed on subscriber demographics, self-reported medical conditions, variables related to the care giver network and variables derived from up to one year of retrospective medical alert data. A 10-fold cross-validation scheme was used to predict transport to the hospital by emergency medical services in the next 30 days. Furthermore, the model performance was evaluated after retraining using up to 90 days of medical alert data, and using enrollment data only.</p>
                </sec>
                <sec sec-type="results">
                    <title>Results</title>
                    <p>Emergency hospital transport in the 30-day window was experienced by 2.4% of all subscribers. The area under the receiver operator characteristic curve (auROC) was 0.75 &#177; 0.01 in the validation cohorts. The model using up to 90 days of data resulted in auROC = 0.71 &#177; 0.01 and the model using enrollment data only resulted in auROC = 0.62 &#177; 0.01.</p>
                </sec>
                <sec sec-type="conclusions">
                    <title>Conclusions</title>
                    <p>Our model for emergency hospital transport in subscribers of a medical alert service showed good discriminatory accuracy on retrospective validation data. While the model yields good discriminatory accuracy with up to 90 days of data, best performance is achieved using up to one year of medical alert data. The model using enrollment data only, without medical alert pattern data, does not perform as well. We are planning a prospective validation of the algorithm to determine the value of the predictive model in assisting HCOs with planning early interventions to avoid emergency department visits and hospitalizations.</p>
                </sec>
            </abstract>
            <kwd-group>
                <kwd>care coordination</kwd>
                <kwd>data analysis</kwd>
                <kwd>emergency medical services</kwd>
                <kwd>personal emergency response service</kwd>
                <kwd>population health management</kwd>
                <kwd>predictive modeling</kwd>
            </kwd-group>
        </article-meta>
    </front>
    <body>
        <p>(This is a conference paper presented at the Connected Health Symposium, Boston, 2015, which was not edited and is only lightly peer-reviewed).</p>
    </body>
    <back>
        <app-group>
            <app id="app1">
                <title>Multimedia Appendix 1</title>
                <p>Extended abstract.</p>
                <media xlink:href="iproc_v1i1e19_app1.pdf" xlink:title="PDF File (Adobe PDF File), 739KB" />
            </app>
        </app-group>
        <ref-list />
    </back>
</article>