<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" article-type="research-article" dtd-version="2.0">
    <front>
        <journal-meta>
            <journal-id journal-id-type="publisher-id">IPROC</journal-id>
            <journal-id journal-id-type="nlm-ta">iProc</journal-id>
            <journal-title>Iproceedings</journal-title>
            <issn pub-type="epub">23696893</issn>
            <publisher>
                <publisher-name>JMIR Publications Inc.</publisher-name>
                <publisher-loc>Toronto, Canada</publisher-loc>
            </publisher>
        </journal-meta>
        <article-meta>
            <article-id pub-id-type="publisher-id">v1i1e5</article-id>
            <article-id pub-id-type="pmid" />
            <article-id pub-id-type="doi">10.2196/iproc.4679</article-id>
            <article-categories>
                <subj-group subj-group-type="heading">
                    <subject>Abstract</subject>
                </subj-group>
                <subj-group subj-group-type="article-type">
                    <subject>Abstract</subject>
                </subj-group>
            </article-categories>
            <title-group>
                <article-title>A Randomized Controlled Trial of an Internet-Delivered Treatment: Its Potential as a Low-Intensity Community Intervention for Adults With Symptoms of Depression</article-title>
            </title-group>
            <contrib-group>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Hale</surname>
                        <given-names>Timothy</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="editor">
                    <name>
                        <surname>Eysenbach</surname>
                        <given-names>Gunther</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Frazier</surname>
                        <given-names>Patricia</given-names>
                    </name>
                </contrib>
                <contrib contrib-type="reviewer">
                    <name>
                        <surname>Lerner</surname>
                        <given-names>Jonathan</given-names>
                    </name>
                </contrib>
            </contrib-group>
            <contrib-group>
                <contrib contrib-type="author" id="contrib1" corresp="yes">
                    <name name-style="western">
                        <surname>Richards</surname>
                        <given-names>Derek</given-names>
                    </name>
                    <degrees>M Sc,, PhD</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <address>
                        <institution>SilverCloud Health</institution>
                        <institution>Clinical Research &#38; Innovation</institution>
                        <addr-line>The Priory,  Johns St West,  Dublin 8</addr-line>
                        <addr-line>Dublin, </addr-line>
                        <country>Ireland</country>
                        <phone>353 0867965581</phone>
                        <fax>353 0867965581</fax>
                        <email>drichard@tcd.ie</email>
                    </address>
                    <xref rid="aff2" ref-type="aff">2</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0003-0871-4078</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib2">
                    <name name-style="western">
                        <surname>Timulak</surname>
                        <given-names>Ladislav</given-names>
                    </name>
                    <degrees>, PhD</degrees>
                    <xref rid="aff2" ref-type="aff">2</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib3">
                    <name name-style="western">
                        <surname>O'Brien</surname>
                        <given-names>Emma</given-names>
                    </name>
                    <degrees>MSc (Applied Psychol</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib4">
                    <name name-style="western">
                        <surname>Hayes</surname>
                        <given-names>Claire</given-names>
                    </name>
                    <degrees>Psy.D.</degrees>
                    <xref rid="aff3" ref-type="aff">3</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib5">
                    <name name-style="western">
                        <surname>Vigano</surname>
                        <given-names>Noemi</given-names>
                    </name>
                    <degrees>MSc (Psych)</degrees>
                    <xref rid="aff1" ref-type="aff">1</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0001-5582-3133</ext-link>
                </contrib>
                <contrib contrib-type="author" id="contrib6">
                    <name name-style="western">
                        <surname>Sharry</surname>
                        <given-names>John</given-names>
                    </name>
                    <degrees>PhD</degrees>
                    <xref rid="aff4" ref-type="aff">4</xref>
                </contrib>
                <contrib contrib-type="author" id="contrib7">
                    <name name-style="western">
                        <surname>Gavin</surname>
                        <given-names>Doherty</given-names>
                    </name>
                    <degrees>D Phil</degrees>
                    <xref rid="aff5" ref-type="aff">5</xref>
                    <ext-link ext-link-type="orcid">http://orcid.org/0000-0002-9617-7008</ext-link>
                </contrib>
            </contrib-group>
            <aff id="aff1">
                <sup>1</sup>
                <institution>SilverCloud Health</institution>
                <institution>Clinical Research &#38; Innovation</institution>
                <addr-line>Dublin</addr-line>
                <country>Ireland</country>
            </aff>
            <aff id="aff2">
                <sup>2</sup>
                <institution>Trinity College Dublin</institution>
                <institution>School of Psychology</institution>
                <addr-line>Dublin</addr-line>
                <country>Ireland</country>
            </aff>
            <aff id="aff3">
                <sup>3</sup>
                <institution>Aware Charity</institution>
                <institution>Clinical Director</institution>
                <addr-line>Dublin</addr-line>
                <country>Ireland</country>
            </aff>
            <aff id="aff4">
                <sup>4</sup>
                <institution>Parents Plus Charity</institution>
                <addr-line>Dublin</addr-line>
                <country>Ireland</country>
            </aff>
            <aff id="aff5">
                <sup>5</sup>
                <institution>Trinity College Dublin</institution>
                <institution>School of Computer Science and Statistics</institution>
                <addr-line>Dublin</addr-line>
                <country>Ireland</country>
            </aff>
            <author-notes>
                <corresp>Corresponding Author: Derek Richards <email>drichard@tcd.ie</email>
                </corresp>
            </author-notes>
            <pub-date pub-type="collection">
                <season>Oct-Dec</season>
                <year>2015</year>
            </pub-date>
            <pub-date pub-type="epub">
                <day>27</day>
                <month>10</month>
                <year>2015</year>
            </pub-date>
            <volume>1</volume>
            <issue>1</issue>
            <elocation-id>e5</elocation-id>
            <!--history from ojs - api-xml-->
            <history>
                <date date-type="received">
                    <day>14</day>
                    <month>5</month>
                    <year>2015</year>
                </date>
                <date date-type="accepted">
                    <day>20</day>
                    <month>7</month>
                    <year>2015</year>
                </date>
            </history>
            <!--(c) the authors - correct author names and publication date here if necessary. Date in form ', dd.mm.yyyy' after jmir.org-->
            <copyright-statement>&#169;Derek Richards, Ladislav Timulak, Emma O'Brien, Claire Hayes, Noemi Vigano, John Sharry, Doherty Gavin. Originally published in JMIR Mhealth and Uhealth (http://www.iproc.org), 27.10.2015. </copyright-statement>
            <copyright-year>2015</copyright-year>
            <license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/">
                <p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mhealth and uhealth, is properly cited. The complete bibliographic information, a link to the original publication on http://mhealth.jmir.org/, as well as this copyright and license information must be included.</p>
            </license>
            <self-uri xlink:href="http://www.iproc.org/2015/1/e5/" xlink:type="simple" />
            <abstract>
                <sec sec-type="background">
                    <title>Background</title>
                    <p>Online delivered treatments for depression have proved successful, with supported programs offering the potential for improved adherence and outcomes. Online support is particularly interesting in the context of increasing access to interventions, and delivering interventions population-wide.</p>
                </sec>
                <sec sec-type="objective">
                    <title>Objective</title>
                    <p>The research investigated if a supported online treatment is effective as a low-intensity community-based intervention for adults with depression. Based on previous successes with supported online treatments for, and the specific Space from Depression program, it was hypothesized that participants in the trial would demonstrate significant decreases in depressive symptoms post-intervention, with corresponding improvements in comorbid anxiety and quality of life indicators.</p>
                </sec>
                <sec sec-type="methods">
                    <title>Methods</title>
                    <p>The study was a randomized controlled trial of a supported 8 module online cognitive behavioral therapy (iCBT) program for adults with depressive symptoms (n=96) compared to a waiting-list control group (n=92). The primary outcome was depressive symptoms. The program was made available nationwide using trained supporters from an established depression charity.</p>
                </sec>
                <sec sec-type="results">
                    <title>Results</title>
                    <p>For the treatment group, post-treatment effect sizes reported were large for the primary outcome measure on depression (d=1.19). The between-group effects were moderate for the primary outcomes (d=0.40) favoring the treatment group. Gains were maintained at 6-month follow-up.</p>
                </sec>
                <sec sec-type="conclusions">
                    <title>Conclusions</title>
                    <p>The results from the present study show that the SilverCloud internet-delivered cognitive-behavior therapy (iCBT) program, Space from Depression, is effective in reducing depressive symptoms in comparison to a waiting list control group. The study demonstrated the potential of an online delivered treatment with online support in a community sample of Irish adults `with symptoms of depression. It gives support to a model for delivering online depression interventions population-wide using trained supporters. In locations where behavioral and mental health services are underdeveloped, or where structures simply do not exist, or where there is a potential to offset risk and escalation of difficulties and benefit from early intervention, such a model of service provision could be feasible.</p>
                </sec>
                <sec>
                    <title>Trial Registration</title>
                    <p>International Standard Randomized Controlled Trial Number (ISRCTN): 03704676; http://www.controlled-trials.com/ISRCTN03704676 (Archived by WebCite at http://www.webcitation/6cWQZmEvw).</p>
                </sec>
            </abstract>
            <kwd-group>
                <kwd>CBT</kwd>
                <kwd>depression</kwd>
                <kwd>Internet delivered</kwd>
                <kwd>online interventions</kwd>
                <kwd>population health</kwd>
                <kwd>randomized trial</kwd>
                <kwd>symptoms</kwd>
                <kwd>treatment</kwd>
            </kwd-group>
        </article-meta>
    </front>
    <body>
        <p>(This is a conference paper presented at the Connected Health Symposium, Boston, 2015, which was not edited and is only lightly peer-reviewed)</p>
    </body>
    <back>
        <app-group>
            <app id="app1">
                <title>Multimedia Appendix 1</title>
                <p>Extended abstract.</p>
                <media xlink:href="iproc_v1i1e5_app1.pdf" xlink:title="PDF File (Adobe PDF File), 487KB" />
            </app>
        </app-group>
        <ref-list />
    </back>
</article>