IPROC iproc Iproceedings 2369-6893 JMIR Publications Toronto, Canada v4i1e10597 10.2196/10597 Abstract Abstract Antibiotics Prescribed Among Patients with Severe Acute Respiratory Illness in Bangladesh Khader Yousef Meraj Chowdhury Nisharga Abdul Aleem M Sabrina M Corresponding Author: Nisharga Meraj Chowdhury nisharga786@gmail.com Jan-Dec2018 29 03 2018 4 1 e10597 29 3 2018 29 3 2018 ©Nisharga Meraj Chowdhury, M Abdul Aleem, M Sabrina. Originally published in Iproceedings (http://www.iproc.org), 29.03.2018. 2018

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in Iproceedings, is properly cited. The complete bibliographic information, a link to the original publication on http://www.iproc.org/, as well as this copyright and license information must be included.

 Background

Proper use of antibiotics helps to minimize the recovery time of patients with severe acute respiratory illness (SARI). Although Bangladesh faces increasing concerns with antimicrobial resistance, there is no national guideline covering preferred antibiotics for SARI cases. Hospital Based Influenza Surveillance (HBIS) identifies SARI patients caused by different microorganism including influenza and other bacterial organisms.

 Objective

We analyzed HBIS data to observe the antibiotic prescription pattern for SARI patients.

 Methods

We analyzed HBIS data from May 2013 to December 2016 from 12 sentinel hospitals regarding length of hospital stay, chronic illness, different classes and generations of antibiotics prescribed to SARI patients. We used proportion test with 95% confidence interval to compare use of different classes of antibiotics.

 Results

Out of 9146 reported SARI cases, 66.3 % were male and 33.7% were female. Among them, 86.6% patients were prescribed antibiotics. Overall, proportion of cephalosporin use was the commonest (54.1%) followed by penicillin (27.3%), macrolides (13.2%) and fluoroquinolones (2.7%). Although use of penicillin was higher (43.5%) than cephalosporin (38.1%) in elderly patients (P<.05). The third-generation cephalosporin was most commonly prescribed (91%). Antibiotic prescription was higher in patients who had no chronic illness (87.2%) than those with asthma (84.1%), hypertension (81.5%) and diabetes (81.1%) (P<0.05 for all comparison). SARI patients who were prescribed macrolides stayed in hospital for shorter period (median 3 days, 2-4 IQR) than those prescribed cephalosporin (median 4 days, 3-6 IQR) and penicillin (median 4 days, 2-6 IQR). In government hospitals cephalosporin was commonly prescribed (69.7%) than non-government hospitals (30.3%) (P<.001).

 Conclusions

Newer generation cephalosporin was most frequently prescribed, which raises the concern of developing antimicrobial resistance. As patients given macrolides had a shorter hospital stay may be recommended for SARI patients. However, development of a national guideline for management of SARI patients including appropriate use of antibiotic is recommended.