IPROC iproc Iproceedings 2369-6893 JMIR Publications Toronto, Canada v8i1e36573 10.2196/36573 Abstract Abstract Prevalence and Factors Associated With Transfusion-Transmitted Infections Among Blood Donors at the National Blood Transfusion and Research Center, Sana’a, Yemen, 2017 Khader Yousef Ghaleb Yasser 1
Yemen Field Epidemiology Training Program Sana'a city Sana'a, 123 Yemen 967 0772265039 ysrghaleb@gmail.com
Alshahar Aymn BSc 2 Ali Majdi BSc 2 Al Amad Mohammed MPH 3 Al Serouri Abdulwahed Prof Dr 3 Yemen Field Epidemiology Training Program Sana'a Yemen National Blood Transfusion and Research Centre Sana'a Yemen Yemen Field Epidemiology Training Program Ministry of Public Health and Population Sana'a Yemen Corresponding Author: Yasser Ghaleb ysrghaleb@gmail.com Jan-Dec 2022 7 2 2022 8 1 e36573 18 1 2022 19 1 2022 ©Yasser Ghaleb, Aymn Alshahar, Majdi Ali, Mohammed Al Amad, Abdulwahed Al Serouri. Originally published in Iproceedings (https://www.iproc.org), 07.02.2022. 2022

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in Iproceedings, is properly cited. The complete bibliographic information, a link to the original publication on https://www.iproc.org/, as well as this copyright and license information must be included.

 Background

 Yemen is facing major challenges in ensuring the safety and availability of blood transfusion to meet the increased demand due to the protracted conflict. However, transfusion-transmissible infectious agents (TTIs) such as hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), syphilis, and malaria remain the greatest threats for blood transfusion safety in such fragile, conflict-affected, and vulnerable settings.

 Objective

The aim of this study was to determine the magnitude of TTIs among blood donors attending the National Blood Transfusion and Research Center (NBTRC) and the associated factors.

 Methods

A cross-sectional study was conducted on 340 blood donors at the NBTRC during November and December 2017. Data were collected through face-to-face interviews using a predesigned questionnaire that covered sociodemographic characteristics and possible TTI-associated factors. Blood samples were drawn and tested for HBV surface antigen (HBsAg), HCV antibodies, HIV1, and HIV2 using electrochemiluminescence immunoassays, and syphilis and malaria antibodies were screened with rapid immunochromatographic techniques.

 Results

The overall prevalence of TTIs was 8.8%, with HBV, HCV, HIV, syphilis, and malaria accounting for 2.5%, 1.2%, 0.3%, 1.2%, and 3.2% of all TTIs, respectively. HBV was significantly associated with a history of jaundice and cupping. Furthermore, urethro-vaginal excretion was significantly associated with syphilis, whereas malaria detection was significantly higher among donors from malaria-endemic areas. Nearly three-quarters of donations were from replacement donors who had a significantly higher TTI prevalence than that of the voluntary donors (10.4% vs 3.3%; odds ratio 3.4, 95% CI 1.1-11.6).

 Conclusions

Although the prevalence of TTIs is low, they still pose a serious risk for blood recipients, especially in fragile, conflict-affected, and vulnerable settings where the needs for blood transfusion are increasing and resources are limited. Therefore, using more sensitive screening methods and establishment of a TTIs surveillance system should be considered. Efforts should be made to improve donor recruitment procedures and increase the proportion of regular and voluntary blood donation.

 transfusion-transmitted infections blood donors HIV syphilis malaria conflict