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Published on 12.12.16 in Vol 2, No 1 (2016): December

This paper is in the following e-collection/theme issue:

    Poster

    Sleep Phenotypes in Chronic Pain Sufferers: Application of Machine Learning to a Large Database

    NeuroMetrix Inc., Waltham, MA, United States

    Corresponding Author:

    Xuan Kong, PhD

    NeuroMetrix Inc.

    1000 Winter Street

    Waltham, MA, 02451

    United States

    Phone: 1 781 314 2722

    Fax:1 781 890 1556

    Email:


    ABSTRACT

    Background: Chronic pain affects over 100 million American adults. There is a negative reciprocal relationship between chronic pain and sleep. As many as 80% of chronic pain patients report poor sleep quality and daytime fatigue. We have recently reported on the clinical benefits of fixed-site high-frequency transcutaneous electrical nerve stimulation (Quell, NeuroMetrix, Inc) in a chronic pain cohort. In addition to delivering therapeutic neurostimulation, this device collects health data including utilization, sleep measures, and activity metrics. The data is communicated to the patient through a smartphone app and aggregated in a cloud server. This digital health database presents a novel opportunity to study population characteristics in a large cohort of chronic pain sufferers.

    Objective: Our primary objective was to use machine learning techniques on a large database of sleep data in chronic pain sufferers to determine “sleep phenotypes.” The long-term goal of this research is to develop personalized therapeutic profiles that optimize sleep in chronic pain patients.

    Methods: De-identified data from device users consenting to have their data uploaded to a cloud server was analyzed. Individual users were characterized by their median sleep data. The analyzed sleep parameters included total sleep time (TST, hours), sleep efficiency (SE, %), periodic leg movement index (PLMI, events/hour), position change rate (PCR, events/hour), and time out of bed (OOB, minutes). K-means clustering was used to partition the data set into 3 mutually exclusive clusters based on TST, PLMI, PCR, and OOB. The optimal number of clusters was determined by the Silhouette value. Clustering was based on the correlation metric. One-way ANOVA was used to test whether the 3 cluster groups had a common mean for each sleep parameter. For parameters with differences in group means, t test was used to identify which pairs of means were different.

    Results: A total of 389 users with 5 or more nights of TST between 4 and 12 hours were included in the analysis. The sizes of the 3 clusters were 161 (41.4%), 147 (37.8%), and 81. None of the sleep parameters had the same mean among three clusters (P<.001). The 3 clusters represented 3 sleep phenotypes. The largest group (n=161) was a “good sleeper” phenotype characterized by a mean TST of 7.3, SE of 95.2, and low PLMI (2.1), PCR (1.3), and OOB (1.4). The second largest cluster was a “moderate sleeper” phenotype characterized by a mean TST of 7.4, SE of 92.4, low PLMI (3.9) and PCR (0.9), but relatively high OOB of 12.7. The third cluster was a “poor sleeper” phenotype characterized by TST of 6.6, SE of 91.2, and a high PLMI of 11.7. All pair-wise cluster means were different (P<.025), except for TST between good and moderate sleepers (P=.452).

    Conclusions: We identified 3 sleep phenotypes in a large cohort of chronic pain sufferers. The phenotypes reflected a progression from good to poor sleepers. The poorer sleepers were characterized by either a large amount of time out of bed during the night or a high rate of periodic leg movements.

    iproc 2016;2(1):e7

    doi:10.2196/iproc.6103

    KEYWORDS


    This poster was presented at the Connected Health Symposium 2016, October 20-21, Boston, MA, United States. The poster is displayed as an image in Figure 1 and as a PDF in Multimedia Appendix 1.

    Figure 1. Poster.
    View this figure

    Multimedia Appendix 1

    Poster.

    PDF File (Adobe PDF File), 226KB

    Edited by T Hale; submitted 05.06.16; peer-reviewed by CHS Scientific Program Committee; accepted 02.08.16; published 12.12.16

    ©Xuan Kong, Thomas C Ferree, Shai N Gozani. Originally published in Iproceedings (http://www.iproc.org), 12.12.2016.

    This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in Iproceedings, is properly cited. The complete bibliographic information, a link to the original publication on http://www.iproc.org/, as well as this copyright and license information must be included.